A. loss
B. liability
C. drag
D. handicap
asset : a useful or valuable thing or person.
loss : the fact or process of losing something or someone.
liability: a person or thing whose presence or behaviour is likely to put one at a disadvantage.
drag : pull (someone or something) along forcefully, roughly, or with difficulty.
handicap : a circumstance that makes progress or success difficult.
Antonym of asset is liability